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KMID : 0352719930170010013
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Journal of Ginseng Research
1993 Volume.17 No. 1 p.13 ~ p.21
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Study on the Hypoglycemic Action of the Fat Soluble Fraction of Panax ginseng C.A. Meyer in Streptozotocin Induced Diabetic Rats
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Abstract
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We attempted in this study to understand the hypoglycemic action of the fat soluble fraction of red ginseng roots in streptozotocin injected diabetic rats, through its actions on several enzymes relating to carbohydrate metabolism of the liver to
compare with those of ginsenosides in streptozotocin injected diabetic rats. It was realized that the increased level of glucose, ketone bodies, lactate, nonesterified fatty acids and triacylglycerol in blood was significantly decreased and the
decreased liver glycogen content of streptozotocin injected rats were appreciably moderated by intraperitoneal injection of the fat soluble fraction of red ginseng roots as shown in the saponin injected diabetic rats. The decreased activities of
liver
enzymes relating to carbohydrate metabolism such as phosphofructokinase, glucokinase, glucose-6phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and acetyl CoA carboxylase of streptozotocin induced diabetic rats were also sufficiently
modified
by the intraperitoneal injection of the above fat soluble fraction as shown in the ginsenoside injected streptozotocin induced rats.
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